...Lissencephaly, which literally means smooth brain, is a rare brain formation disorder caused by defective neuronal migration during the 12th to 24th weeks of gestation, resulting in a lack of development of brain folds (gyri) and grooves (sulci).Dobyns, WB. Developmental aspects of lissencephaly and the lissencephaly syndromes. Birth Defects Orig Artic Ser 1987; 23:225. It is a form of cephalic disorder. Terms such as 'agyria' (no gyri) or 'pachygyria' (broad gyri) are used to describe the appearance of the surface of the brain. Children with lissencephaly are severely neurologically impairedBauman, ML. Neuroembryology--clinical aspects. Semin Perinatol 1987; 11:74. and often die within several months of birth.Jones, KL. Smith's Recognizable Patterns of Human Malformation, 6th ed. Elsevier Saunders, Philadelphia 2006. Read full entry
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- top-health-site.com
- 1.Lissencephaly - Wikipedia, the free encyclopedia
- Lissencephaly, which literally means smooth brain, is a rare brain formation ... Causes of lissencephaly can include viral infections of the uterus or the fetus ...
- http://en.wikipedia.org/wiki/L
issencephaly
- 2.Lissencephaly Information Page: National Institute of ...
- Lissencephaly information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS) ... What is Lissencephaly? Is there any ...
- http://www.ninds.nih.gov/disor
ders/lissencephaly/lissencepha ly.htm
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Can anyone tell me all about I need to know what it is and
just everything it does plus
more stuff about it.
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Lissencephaly is an abnormality of the brain which causes severe mental retardation and poor motor control similar to cerebral palsy. Most people with the condition have a short life span. Lissencephaly literally means "smooth brain" and it is called this because, unlike a normally developed brain which has lots of folds and ridges, the lissencephalic brain appears smooth. A good start for much more information is www.lissencephaly.org. |
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Looking for top geneticists in We have an 8 month old dx.
with Lissencephaly,
Miller-Dieker studies are
normal, high-resolution
chromosomes 46, XY, and FISH
for 22q11.2 deletion were
normal, Lysosomal studies had
some values lower than normal.
MRI taken 3 days after
delivery showed generalized
lack of sulcation of the
cerebral and cerebellar
hemispheres, no brain
parenchymal hemorrhage, corpus
callosum is present,
generalized cerebral and
cerebellar volume loss, no
hydrocephalus, no abnormal
extra-axial fluid collections.
At this time our baby is
reaching all developmental
milestones...any help would be
great.
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Lissencephaly Network http://www.lissencephaly.org/ http://homepage.ntlworld.com/f oliot/liss/ This has mega info & chat groups, as well as a national registry Chat group: http://health.groups.yahoo.com /group/lissencephaly/ |
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does anyone know anything |
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Lissencephaly is a set of rare brain disorders and you will probably find that very few people have heard of it. Lissencephaly is used as an 'umbrella' term to describe a range of disorders where the whole or parts of the surface of the brain appear smooth. How is it caused? We know that in Lissencephaly the brain develops normally in early pregnancy but then fails to progress normally after the third to fourth month. There are several causes and these can be identified in many children. The different types of Lissencephaly generally have different causes. These fall into four main categories: An inherited genetic condition that may come from either one or both parents; A new genetic mutation (i.e not inherited) that occurs in a gene that is critical for the correct development of the brain; An infection from a virus during pregnancy; An interruption of the blood supply to the foetus during pregnancy. |
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