Noun
- A congenital disorder involving insufficient division of the lobes of the brain during fetal development, resulting in skull and facial deformities ranging from minor cleft lip problems to cyclopia, in which a single eye develops where the nose would normally be.
Read full definition at wiktionary.org
...Holoprosencephaly (HPE, once known as arhinencephaly) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to develop into two hemisphere. Normally, the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. Hox genes, which guide placement of embryonic structures, fail to activate along the midline of the head, allowing structures that are normally paired on the left and right to merge. The condition also occurs in other species, as with Cy, the Cyclops kitten. Read full entry
This entry is from Wikipedia,the leading user-contributed encyclopedia.It may not have been reviewed by professional editors(See full disclaimer)
- 1.Holoprosencephaly - Wikipedia, the free encyclopedia
- Holoprosencephaly (HPE, once known as arhinencephaly) is a cephalic disorder in ... Symptoms of holoprosencephaly range from mild (no facial/organ defects, anosmia, ...
- http://en.wikipedia.org/wiki/H
oloprosencephaly
- 2.Holoprosencephaly - Holoprosencephaly
- Information, resources, and support for families of children born with holoprosencephaly. ... Welcome to Holoprosencephaly.net This website was created by ...
- http://www.holoprosencephaly.n
et/
 |
What is holoprosencephaly and |
|
 |
|
|
 |
Holoprosencephaly is a relatively common birth defect of the brain, which often also affects facial features, causing closely spaced eyes, small head size, and sometimes clefts of the lip and roof of the mouth. I don't know how you can become a holoprosencephalist |
|
|
|
|
|
What is an "Amadeus Ventricle" Part 1, Section 1, Page 7 of
Diagnostic Imaging Pediatric
Neuroradiology says that you
can see an "Amadeus ventricle"
on axial MR images in alobar
holoprosencephaly. Dahnert,
Neuroradiology Requisites,
Stedman's, and Yahoo and
Google searches returned no
results. Does anyone know what
it is? Serious informed
answers only please.
|
|
|
|
|
|
Holoprosencephaly is a type of cephalic disorder. This is a disorder characterized by the failure of the prosencephalon (the forebrain of the embryo) to develop. During normal development the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. (The condition also occurs in other species, as with Cy, the Cyclops kitten.) Holoprosencephaly is caused by a failure of the embryo's forebrain to divide to form bilateral cerebral hemispheres (the left and right halves of the brain), causing defects in the development of the face and in brain structure and function. Symptoms of holoprosencephaly range from mild (anosmia, or a single central incisor) to moderate (cleft lip or palate) to severe (synophthalmia proboscis or cyclopia). There are three classifications of holoprosencephaly. Alobar holoprosencephaly, the most serious form in which the brain fails to separate, is usually associated with severe facial anomalies. Semilobar holoprosencephaly, in which the brain's hemispheres have a slight tendency to separate, is an intermediate form of the disease. Lobar holoprosencephaly, in which there is considerable evidence of separate brain hemispheres, is the least severe form. In some cases of lobar holoprosencephaly, the patient's brain may be nearly normal. |
|
|
|
|
|
Do you know anything about My pregnancy ended at 5 months
because I was diagnosed with
this. The baby had only half a
brain and severe deformities.
My heart aches so bad that I
can't stand it. Does anyone
know if this is genetic? I
would love to talk with
someone else in a similar
situation. This just happened
last week. I do not think I
will ever be the same again.
|
|
|
|
|
|
Time will heal the open emotional wounds, though you will always have a special part in your heart for the pregnancy you lost. I worked in the field of developmental disabilities for twenty years and experience thru family and work the heart aches, joys and frustrations of having a special needs child. The term you want is holoprosencephaly,the failure of the prosenceplon section of the forebrain (the part of the brain). Go to www.wedmd.com and you will be able to read on the diagnosis, which I believe applies to the baby rather than the mother. Contact your local health department and ask who in your state does genetic studies? The geneticist can answer your questions and do the medical studies to help you determine if there is a genetic issue that will help you to decide about having a baby. |
|
|
|
|
* Indicates a required fieldAdd your knowledge or ask a question:
