...

Pharmacology

Galantamine in its pure form is a white powder. Galantamine is a competitive and reversible cholinesterase inhibitor. It is believed it works by enhancing cholinergic function by increasing the concentration of acetylcholine in the brain. The atomic resolution 3D structure of the complex of galantamine and its target, acetylcholinesterase, was determined by X-ray crystallography in 1999 (PDB code: 1DX6; see complex).Greenblatt, HM, Kryger, G, Lewis, T, Silman, I, Sussman, JL "Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3Å resolution" FEBS Lett 1999; 463, 321-26. PMID 10606746 There is no evidence that galantamine alters the course of the underlying dementing process.Ortho-McNeil Neurologics, "Razadyne ER US Product Insert", May 2006. [1] Galantamine has also shown activity in modulating the nicotinic cholinergic receptor to increase acetylcholine release. Woodruff-Pak DS, Vogel RW 3rd, Wenk GL, "Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning" Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2089-94. PMID 11172080 Read full entry

This entry is from Wikipedia,the leading user-contributed encyclopedia.It may not have been reviewed by professional editors(See full disclaimer)